CCRT

CCRT hosts the 10th International Symposium on Translational Research in Oncology

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Thursday September 28th, Friday September 29th and Saturday September 30th 2017.

Mezzanine Suite, Herbert Park Hotel, Ballsbridge, Dublin 4
Chairs: Prof John Crown & Prof Robert Kerbel
CPD Accredited

For full programme details please click here:

Invitation and Programme Final – 10th International Symposium on Translational Research in Oncology.

Summer Sizzle in aid of CCRT, Railway Union RFC, Saturday June 10th from 4pm

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Raffle tickets available on Eventbrite or at Michael Byrne Craft Butchers.

https://www.eventbrite.ie/e/sandymount-summer-sizzle-tickets-34631841771

Michael Byrne and Sons Craft Butchers, 92 sandymount Road, Sandymount, Dublin 4

Further details available at: www.facebook.com/SandymountSummerSizzl/

We are very grateful to the organisers in selecting the Cancer Clinical Research Trust as the beneficiary of this exciting event.

Fun, pre-Christmas Quiz Night in aid of CCRT

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For a fun, pre-Christmas night out make your way to the Goat Grill, Goatstown, on Thursday December 1st for a fundraising Quiz Night in aid of CCRT! Make it your work Christmas night out!

€15 per person (€60 table of four). Tickets available from Tom Flynn email: tomflynn08@gmail.com.

Great prizes up for grabs in the raffle on the night!

Huge thanks to the Flynn family for their fantastic fundraising efforts to date in memory of their Dad, Barry (RIP), and for their dedication in organising this night out in aid of CCRT and cancer research.

CCRT hosts the 9th International Symposium on Translational Research in Oncology

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PROGRAMME

Friday, 30th September, Mezzanine Suite, Herbert Park hotel
Chairs: Prof John Crown & Prof Robert Kerbel
CPD Accreditation: 6 points

Registration from 11:00

IMMUNOTHERAPY
11:30-12:00 Development of immune therapies beyond PD-1 and CTLA-4 blockade
Dr Mario Sznol, Yale Cancer Centre

12:00-12:30 Clinical trials of oxygenation agents and antagonists of A2a adenosine receptors to enable tumor rejection by immunotherapies of cancer
Prof Michail Siktkovsky, Northeastern University, Boston

12:30-1:00 Talimogene laherparepvec, first approved oncolytic immunotherapy
Dr Ohrling Katarina, Amgen Inc.

1:00-1:45 Lunch, Herbert Suite

NOVEL THERAPIES
1:45-2:15 Ribociclib – mechanism of action, preclinical and early clinical development
Dr Thomas Bachelot, Centre Leon Berard, Lyon, France

2:15-2:45 Eribulin mechanisms of action: Beyond antimitotic effects to complex changes in tumour biology
Dr Bruce Littlefield, Eisai Inc.

ANGIOGENESIS
2:45-3:15 The biology of angiogenesis and the challenge of identifying anti-angiogenesis biomarkers in oncology
Dr Annette Byrne, Royal College of Surgeons in Ireland

3:15-3:45 Implications of ‘vessel co-option’ by tumors for antiangiogenic therapy of metastatic disease
Prof Robert Kerbel, Sunnybrook Health Science Centre, Toronto

3:45-4:00 Coffee break, Herbert Suite

TARGETING CELL SIGNALLING
4:00-4:30 The PI3K pathway in cancer
Prof Bryan Hennessy, Royal College of Surgeons in Ireland

4:30-5:00 Targeting the IGF signaling network in cancer with the IGF-1/-2 ligand neutralizing antibody BI 836845 – an update
Dr Thomas Bogenrieder, Boehringer Ingelheim

5:00-5:30 Neratinib for treatment of HER2 mutant, non-amplified breast cancers
Dr Alshad Lalani, Puma Biotechnology Inc.

5:30-6:00 A brief TOR of vistusertib: translating the science into the clinic
Dr Christopher Shepherd, AstraZeneca UK Limited

Saturday 1st October, Mezzanine Suite, Herbert Park Hotel
Chairs: Prof John Crown & Prof Robert Kerbel
CPD Accreditation: 3 points

PERSONALIZED CANCER MEDICINE
9:00-9:30 Next Generation Sequencing of FFPE samples in development cohorts and a large randomized trial (ER pos HER2 neg breast cancer).
Dr Christer Svedman, Genomic Health

9:30-10:00 Hybrid-capture based liquid biopsy allows the detection of diverse genomic alterations
Dr Judith Müller, NEO New Oncology

10:00-10.30 HER2 testing: Past and present
Prof Mike Press, University of Southern California

10:30-10:50 Coffee break, Herbert Suite

DNA DAMAGE/REPAIR
10:50-11:20 Mutant p53 as a target for the treatment of triple-negative breast cancer
Prof Joe Duffy, St Vincent’s University Hospital/University College Dublin

11:20-11:50 Targeting ATR as an attractive anti-cancer approach
Dr John Pollard, Vertex Pharmaceuticals

11:50-12:20 Talazoparib pharmacology: Clinical potential for PARP inhibition and PARP trapping
Dr Vernon Phan, Medivation Inc.

12:20-1:20 Lunch, Herbert Suite

DIVERSITY/GENOMIC INSTABILITY
1:20-1:50 Immune sculpting of the breast cancer genome
Prof Lajos Pusztai, Yale Cancer Center Genetics, Genomics and Epigenetics Program

1:50-2:20 Clonal diversity and genomic drivers of exceptional responses
Prof Michael Barrett, Mayo Clinic Cancer Centre, Arizona

2:20-2:50 DNA instability in solid tumours – the key to curing cancer?
Prof Ken O’Byrne, Princess Alexandra Hospital, Queensland University of Technology

2:50-3:10 Coffee break, Herbert Suite

TARGETING TRANSCRIPTIONAL REGULATION
3:10-3:40 Improving cancer therapy via CDK8/19 Mediator kinase
Prof Igor Roninson, University of South Carolina

3:40-4:10 The potential of inecalcitol, a vitamin D receptor agonist, in hematologic malignancies
Dr Remi Delansorne, Hybrigenics

TARGETING CYCLIN DEPENDENT KINASES
4:10-4:40 Preclinical activity of abemaciclib as a single agent or in combination with anti-mitotic or targeted therapies for breast cancer
Dr Neil O’Brien, Department of Medicine, UCLA

4:40-5:10 Development of palbociclib from pre-clinical assessment to global registration: A paradigm for development of CDK 4/6 inhibitors
Dr Rich Finn, Geffen School of Medicine, UCLA

The Great Fragola Brothers Trilogy

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Once again a huge thank you must go to the wonderful author Joe Prendergast. For those of you who don’t already know, Joe has penned a trilogy on the The Great Fragola Brothers with all proceeds from the sales of the books going to the Cancer Clinical Research Trust.

For anyone who would like to be swept up in the excitement of the Fragola Brothers advenutres, the books can be purchased through the website Emu Ink

Joe’s love of writing began at an early age but in 2012 when only in 5th Class in Holy Trinity school, Sandyford, Dublin he wrote his first book – The Great Fragola Brothers, to which he then penned a sequel; The Great Fragola Brothers, The Twisted and now The Great Fragola Brothers, Dead End.

Joe was inspired to write these books after his beloved father Geoff died of lung cancer. In his memory Joe chose to donate the profits from his books to Cancer Clinical Research Trust (CCRT).

We are very grateful to Joe for such continued generosity and would like to wish him well in wherever the world of publishing takes him next!

DUNDRUM ARTS AND CULTURAL FESTIVAL – FUNDRAISING EVENING FOR CCRT – THANK YOU!

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On Tuesday, 23rd June at 8pm, a choral event was held at Holy Cross Church, Dundrum.

Run by Christine Cosgrave and her husband Kevin, it was a great success and a most enjoyable evening.

Professor John Crown (Director, CCRT) dropped by and he was full of praise for the event. Christine and Kevin have been wonderful supporters to CCRT and we are extremely grateful.

Our thanks to all who supported the event and to all the choral groups who gave of their talents on the night.

KILLARNEY RACEGOERS CLUB – FUNDRAISING EVENT AT THE KILLARNEY RACES, IN MEMORY OF JEREMY O’NEILL

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CCRT is most grateful to the Killarney Racegoers Club for holding this event, in memory of their good friend Jeremy O’Neill.   Jeremy had a great love of horses and racing and so it was a fitting tribute to him, while raising much-needed funds for cancer research.

The event went extremely well and we thank both the organizers and those who attended the event and contributed so generously .

Professor John Crown (Director, CCRT) attended and he thoroughly enjoyed the day!

THANK YOU ALL SO VERY MUCH

THE CCRT TEAM

SHELBOURNE EASTER EGG RAFFLE – RESULT!!!!!

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We have the raffle yesterday!!  The winner was   – feel free to insert a drum roll here!!!!…………..AOIFE FLOOD!!  She is delighted to win.

Thanks to everyone for the support.  Thanks to the Shelbourne Hotel for donating the beautiful egg and indeed afternoon tea for two!

We are grateful to Dolores and Faith for working on this initiative for us and to Phill for coming to oversee the raffle draw itself.

 

HAPPY EASTER!CCRT Egg